Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau
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چکیده
منابع مشابه
Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau
Age-related neurodegenerative disease has been mechanistically linked with mitochondrial dysfunction via damage from reactive oxygen species produced within the cell. We determined whether increased mitochondrial oxidative stress could modulate or regulate two of the key neurochemical hallmarks of Alzheimer's disease (AD): tau phosphorylation, and beta-amyloid deposition. Mice lacking superoxid...
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The m-AAA protease subunit AFG₃L₂ is involved in degradation and processing of substrates in the inner mitochondrial membrane. Mutations in AFG₃L₂ are associated with spinocerebellar ataxia SCA28 in humans and impair axonal development and neuronal survival in mice. The loss of AFG₃L₂ causes fragmentation of the mitochondrial network. However, the pathogenic mechanism of neurodegeneration in th...
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As you can see the referees find the analysis interesting and suitable for the EMBO Journal, but further analysis is also needed. In particular, more direct measurements of ROS levels should be performed, off-targets effects should be ruled out, better statistical analysis performed and some more insight into why there is a loss of mitochondria in afg3l2 neurons. Should you be able to able to a...
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Alzheimer's disease (AD) is the most common form of dementia. The pathological hallmarks of AD are amyloid plaques [aggregates of amyloid-beta (Aβ)] and neurofibrillary tangles (aggregates of tau). Growing evidence suggests that tau accumulation is pathologically more relevant to the development of neurodegeneration and cognitive decline in AD patients than Aβ plaques. Oxidative stress is a pro...
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In normal adult brain the microtubule associated protein (MAP) tau contains 2-3 phosphates per mol of the protein and at this level of phosphorylation it is a soluble cytosolic protein. The normal brain tau interacts with tubulin and promotes its assembly into microtubules and stabilizes these fibrils. In Alzheimer disease (AD) brain tau is three to fourfold hyperphosphorylated. The abnormally ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2007
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0000536